| Title | Genetic mechanisms of critical illness in Covid-19 |
| DOI | https://doi.org/10.1038/s41586-020-03065-y |
| Method | Microarray, Whole genome sequencing and Genome wide association study |
| Curator 1 | megan |
| Curator 2 | tsaone |
| Population | Pairo-Castineira |
| Published | Yes |
| Variant detail | Description of Comparison | Gene | RSID | Association | Disease Status | MAF | Statistical Odds Ratio | Statistical P-value |
| Variant | Pairo-Castineira_rs10735079 | Critical COVID vs controls UKB | OAS3,OAS2,OAS1 | rs10735079 | Positive | Critical | None | 1.3 | 1.60e-08 |
| Variant | Pairo-Castineira_rs11085727 | hospitalised vs controls | TYK2 | rs11085727 | Positive | Severe | None | 1.2 | 1.20e-13 |
| Variant | Pairo-Castineira_rs13050728 | Hospitalised vs Controls | IFNAR2 | rs13050728 | Positive | Severe | None | 1.2 | 5.10e-12 |
| Variant | Pairo-Castineira_rs143334143 | Critical COVID vs controls UKB | CCHCR1 | rs143334143 | Positive | Critical | None | 1.8 | 8.80e-18 |
| Variant | Pairo-Castineira_rs143334143 | hospitalised vs controls | CCHCR1 | rs143334143 | Positive | Severe | None | 1.3 | 1.50e-10 |
| Variant | Pairo-Castineira_rs2109069 | Critical COVID vs controls UKB | DPP9 | rs2109069 | Positive | Critical | None | 1.4 | 4.00e-12 |
| Variant | Pairo-Castineira_rs2109069 | hospitalised vs controls | DPP9 | rs2109069 | Positive | Severe | None | 1.2 | 7.00e-13 |
| Variant | Pairo-Castineira_rs2236757 | Critical COVID vs controls UKB | IFNAR2 | rs2236757 | Negative | Critical | None | 1.3 | 5.00e-08 |
| Variant | Pairo-Castineira_rs3131294 | Critical COVID vs controls UKB | NOTCH4 | rs3131294 | Positive | Critical | None | 1.5 | 2.80e-08 |
| Variant | Pairo-Castineira_rs6489867 | hospitalised vs controls | OAS1, OAS2, OAS3 | rs6489867 | Negative | Severe | None | 1.2 | 9.70e-10 |
| Variant | Pairo-Castineira_rs71325088 | hospitalised vs controls | LZTFL1, LOC107986083, SLC6A20, SACM1L, CCR9, FYCO1, XCR1, CCR1, CCR3 | rs71325088 | Positive | Severe | None | 1.9 | 2.50e-54 |
| Variant | Pairo-Castineira_rs73064425 | Critical COVID vs controls UKB | LZTFL1, FYCO1,CXCR6,CCR2,CCR3, SLC6A20 | rs73064425 | Positive | Critical | None | 2.1 | 4.80e-30 |
| Variant | Pairo-Castineira_rs74956615 | Critical COVID vs controls UKB | RAVER1, FDX2, ICAM1, ICAM4, ICAM5, ZGLP1, ICAM3, TYK2 | rs74956615 | Positive | Critical | None | 1.6 | 2.30e-08 |
| Variant | Pairo-Castineira_rs9380142 | Critical COVID vs controls UKB | HLA-G | rs9380142 | Positive | Critical | None | 1.3 | 3.20e-08 |
