Variant Detail

RSID rs73064425
HGVS NC_000003.11:g.45901089C>T NC_000003.12:g.45859597C>T
Chromosome 3
Start position45901089
Stop position45901089
Associated gene(s)LZTFL1, SLC6A20, CCR9, FYCO1, CXCR6, XCR1, CCR1, CCR3
Mutation typeTagged SNP
Reference C
Alternative T
Associated allele T
Associated African Allele Frequency 0.0139
Consequence Intronic
Other population frequencies linkALFA rs73064425

Variants

NamePaperDescription of ComparisonGeneRSIDAssociationDisease StatusMAFStatistical Odds RatioStatistical P-value
Horowitz_rs73064425 Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease Meta analysis, External data LZTFL1, CCR9, SLC6A20, FYCO1, CXCR6, XCR1, CCR1, CCR3 rs73064425 Positive Severe 0.07 1.42 0.00000000007
Pairo-Castineira_rs73064425 Genetic mechanisms of critical illness in Covid-19 Critical COVID vs controls UKB LZTFL1, FYCO1,CXCR6,CCR2,CCR3, SLC6A20 rs73064425 Positive Critical None 2.1 0.0000000000000000000000000000048
Horowitz_2_rs73064425 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease severe COVID-19 vs COVID-19negative or unknown LZTFL1, LOC107986083, SLC6A20, SACM1L, CCR9, FYCO1, XCR1, CCR1, CCR3 rs73064425 positive Susceptibility 7.0 1.58 0.000000000000000002
Horowitz_2_rs73064425 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease COVID-19 severe vs not hospitalised LZTFL1, LOC107986083, SLC6A20, SACM1L, CCR9, FYCO1, XCR1, CCR1, CCR3 rs73064425 positive Severe None 1.59 0.00000000000000428

Papers

Paper
Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease
Genetic mechanisms of critical illness in Covid-19
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease