Variant Detail

RSID rs2109069
HGVS NC_000019.10:g.4719431G>A
Chromosome 19
Start position4719431
Stop position4719431
Associated gene(s)DPP9
Mutation typeTagged SNP
Reference G
Alternative A
Associated allele A
Associated African Allele Frequency 0.2212
Consequence Intronic
Other population frequencies linkALFA rs2109069

Variants

NamePaperDescription of ComparisonGeneRSIDAssociationDisease StatusMAFStatistical Odds RatioStatistical P-value
Horowitz_rs2109069 Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease Meta analysis, External data DPP9 rs2109069 Positive Severe 0.31 1.06 0.0001
Pairo-Castineira_rs2109069 Genetic mechanisms of critical illness in Covid-19 Critical COVID vs controls UKB DPP9 rs2109069 Positive Critical None 1.4 0.000000000004
Pairo-Castineira_rs2109069 Genetic mechanisms of critical illness in Covid-19 hospitalised vs controls DPP9 rs2109069 Positive Severe None 1.2 0.0000000000007
COVID-19 HGI_rs2109069 Mapping the human genetic architecture of COVID-19 Hospitalised vs Controls DPP9 rs2109069 Positive Severe 0.312 1.154 0.0000000000000000276
COVID-19 HGI_rs2109069 Mapping the human genetic architecture of COVID-19 Critical vs Controls DPP9 rs2109069 Positive Critical 0.316 1.26 0.000000000000000000000968
Li_rs2109069 Genome-wide association study of COVID-19 severity among the Chinese population severe vs control (Huoshenshan cohort) DPP9 rs2109069 positive Severe None 1.33 0.032
Horowitz_2_rs2109069 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease Hospitalised COVID-19 vs negative/unknown DPP9 rs2109069 positive Susceptibility 31.0 1.1 0.0000003
Horowitz_2_rs2109069 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease COVID-19 hospitalised vs not hospitalised DPP9 rs2109069 positive Severe None 1.08 0.000566

Papers

Paper
Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease
Genetic mechanisms of critical illness in Covid-19
Mapping the human genetic architecture of COVID-19
Genome-wide association study of COVID-19 severity among the Chinese population
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease