Population name | Asselta |
Genome | GRCh37 |
Consortium | None Specified |
Super population | EUR |
Population description | Italian |
Population origin | Southern Europe |
Case population size | 7268 |
Control population size | 84450 |
Comorbidities | Not specified |
Mean / median age | Not Specified |
Sex | Not specified |
Severity | NA |
Sample source | NA |
Method | Whole exome sequencing (WES) and genome-wide microarray genotyping data analysis |
Bioinformatics | Expression: GTex repository and GEO database
Burden analysis: LRT score, MutationTaster, PolyPhen-2 HumDiv, PolyPhen-2 HumVar, and SIFT |
Imputation details | Michigan Imputation server
Reference panel: 1000G Phase 3 v5
Phasing: ShapeIT v2.r790
Software: Minimac3
Filters: r2>0.3 |
Limitations | Analysed genetic data for only two candidate genes
No confounding issues addressed
This was an exploratory study that did not include any genetic data from patients infected with SARS-CoV-2, therefore there is a need for experimental data. |