Population

Population name Asselta
Genome GRCh37
Consortium None Specified
Super population EUR
Population description Italian
Population origin Southern Europe
Case population size 7268
Control population size 84450
Comorbidities Not specified
Mean / median age Not Specified
Sex Not specified
Severity NA
Sample source NA
Method Whole exome sequencing (WES) and genome-wide microarray genotyping data analysis
Bioinformatics Expression: GTex repository and GEO database Burden analysis: LRT score, MutationTaster, PolyPhen-2 HumDiv, PolyPhen-2 HumVar, and SIFT
Imputation details Michigan Imputation server Reference panel: 1000G Phase 3 v5 Phasing: ShapeIT v2.r790 Software: Minimac3 Filters: r2>0.3
Limitations Analysed genetic data for only two candidate genes No confounding issues addressed This was an exploratory study that did not include any genetic data from patients infected with SARS-CoV-2, therefore there is a need for experimental data.