Variant Detail

RSID rs2236757
HGVS NC_000021.9:g.33252612=
Chromosome 21
Start position33252612
Stop position33252612
Associated gene(s)IFNAR2
Mutation typeTagged SNP
Reference A
Alternative G
Associated allele A
Associated African Allele Frequency 0.2144
Consequence Intronic
Other population frequencies linkALFA rs2236757

Variants

NamePaperDescription of ComparisonGeneRSIDAssociationDisease StatusMAFStatistical Odds RatioStatistical P-value
Horowitz_rs2236757 Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease Meta analysis, External data IFNAR2 rs2236757 Negative Severe 0.29 1.13 0.0002
Pairo-Castineira_rs2236757 Genetic mechanisms of critical illness in Covid-19 Critical COVID vs controls UKB IFNAR2 rs2236757 Negative Critical None 1.3 0.00000005
Horowitz_2_rs2236757 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease Hospitalised COVID-19 vs negative/unknown IFNAR2 rs2236757 positive Susceptibility 29.0 1.08 0.00007
Horowitz_2_rs2236757 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease COVID-19 hospitalised vs not hospitalised IFNAR2 rs2236757 positive Severe None 1.08 0.00176

Papers

Paper
Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease
Genetic mechanisms of critical illness in Covid-19
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease