Population

Population name Roberts
Genome GrCH37
Consortium Ancestry DNA
Super population EUR, AMR
Population description European ancestry- (65%) Admixed African-European ancestry includes 100% African ancestry-(6%) Admixed Amerindian ancestry also includes 100% Amerindian ancestry-(11%) Other including Admixed East Asian-European ancestry also includes 100% East Asian ancestry- (18%)
Population origin Northern America
Case population size 2417
Control population size 14993
Comorbidities Asthma, Cardiovascular disease, diabetes, hypertension, autoimmune disease, rare health conditions (proportions specified in supplementary data)
Mean / median age 56
Sex 862 male; 1555 female
Severity Susceptibility
Sample source Nasopharyngeal swab
Method GWAS; Illumina genotyping array
Bioinformatics Linkage disequilibrum (LD)-pruned using PLINK 1.9 COVID-19 Host Genetics Initiative analysis plan version 1 using PLINK 2.0 for GWAS analysis
Imputation details Haplotype Reference Consortium (HRC) reference panel Haplotypes : Eagle version 2.4.1 Software: Minimac4 (MAF)>0.01 R2>0.30
Limitations Participants required to fill out a survey therefore cases that were very severe or fatal would not be included Participants restricted to European ancestry due to small numbers from other ancestral groups No independent replication cohort to determine if results are reproducible Did not assess indels