| Population name | Chen |
| Genome | GRCh37 |
| Consortium | Vanderbilt University Medical Center biobank |
| Super population | EUR AFR |
| Population description | European and African American ancestry |
| Population origin | Not specified |
| Case population size | 10599 |
| Control population size | 74638 |
| Comorbidities | Obesity, COPD, diabetes, CVD, liver and renal disease, asthma, dyslipidemia and hypertension |
| Mean / median age | 52.1 EUR 37.2 AFR |
| Sex | 51.1% male EUR, 45.9% male AFR |
| Severity | NA |
| Sample source | NA |
| Method | Illumina Expanded Multi-Ethnic Genotyping Array (MEGAEX)was used for genotyping. Replication was verified using two independent datasets from UK Biobank (UKB) and non overlapping Vanderbilt University biobank (BioUV) data. Top findings in the study were analysed in the COVID-19 Host Genetics Initiative (COVID-19 HGI) meta-analysis summary statistics from the July 2, 2020 release. |
| Bioinformatics | SNPs with an imputation info score greater than 0.4 and minor allele frequency (MAF) greater than 1% were used for further GWAS and GReX imputation. More stringent cut offs used for AFR individuals because of smaller sample size. SUGEN was used to remove known family relatedness and PRIMUS used to reconstruct non directional family networks with ERSA verifying families with more then 5 members. LD patterns analysed on HaploView V. 4.2. |
| Imputation details | Genetic imputation in MEGAEX-genotyped subjects was conducted with minimac4 on the Michigan Imputation Server12 with a reference panel of Haplotype Reference. |
| Limitations | Phenotypes were extracted from electronic health records which can affect classification of cases. Pneumonia cases were based on clinical evidence and not lab based testing |