COVID image

COHG-SA

Paper Detail

TitleMapping the human genetic architecture of COVID-19
DOI https://doi.org/10.1038/s41586-021-03767-x
MethodGenome wide association study
Curator 1fatima
Curator 2admin
Population COVID-19-HGI
Published Yes
Variant detailDescription of ComparisonGeneRSIDAssociationDisease StatusMAFStatistical Odds RatioStatistical P-value
Variant COVID-19 HGI_10490770 Hospitalised vs Controls LZTFL1, CXCR6, LOC107986083 rs10490770 Positive Severe 0.081 1.649 1.44e-73
Variant COVID-19 HGI_10490771 Critical vs Controls LZTFL1, CXCR6, LOC107986083 rs10490770 Positive Critical 0.075 1.885 2.20e-61
Variant COVID-19 HGI_rs10774671 Hospitalised vs Controls OAS1, OAS2, OAS3 rs10774671 Positive Severe 0.664 1.107 6.14e-10
Variant COVID-19 HGI_rs10774671 Critical vs Controls OAS1, OAS2, OAS3 rs10774671 Positive Critical 0.652 1.2 4.08e-13
Variant COVID-19 HGI_rs11918389 Susceptibility vs Control RPL24, CEP97, NXPE3, ZBTB11 rs11918389 Negative Mild 0.354 0.941 3.46e-15
Variant COVID-19 HGI_rs13050728 Hospitalised vs Controls IFNAR2 rs13050728 Negative Severe 0.651 0.861 2.72e-20
Variant COVID-19 HGI_rs13050728 Critical vs Controls IFNAR2 rs13050728 Negative Critical 0.652 0.819 1.05e-16
Variant COVID-19 HGI_rs1819040 Hospitalised vs Controls KANSL1, ARHGAP27, PLEKHM1, LINC02210-CRHR1, CRHR1, SPPL2C, MAPT, STH, LRRC37A, ARL17B, LRRC37A2, ARL17A, NSF, WNT3 rs1819040 Negative Severe 0.186 0.879 1.83e-10
Variant COVID-19 HGI_rs1886814 Hospitalised vs Controls FOXP4 rs1886814 Positive Severe 0.042 1.262 1.11e-09
Variant COVID-19 HGI_rs2109069 Hospitalised vs Controls DPP9 rs2109069 Positive Severe 0.312 1.154 2.76e-17
Variant COVID-19 HGI_rs2109069 Critical vs Controls DPP9 rs2109069 Positive Critical 0.316 1.26 9.68e-22
Variant COVID-19 HGI_rs2271616 Susceptibility vs Control SLC6A20, CCR3, LOC107986082 rs2271616 Positive Mild 0.118 1.155 1.79e-34
Variant COVID-19 HGI_rs4801778 Susceptibility vs Control PLEKHA4, PPP1R15A, TULP2, NUCB1, HSD17B14 rs4801778 Negative Susceptibility 0.18 0.946 1.18e-08
Variant COVID-19 HGI_rs529565 Susceptibility vs Control ABO rs529565 Negative Susceptibility 0.651 0.905 1.45e-39
Variant COVID-19 HGI_rs72711165 Hospitalised vs Controls TMEM65 rs72711165 Positive Severe 0.013 1.37 2.13e-09
Variant COVID-19 HGI_rs74956615 Hospitalised vs Controls RAVER1, FDX2, ICAM1, ICAM4, ICAM5, ZGLP1, ICAM3, TYK2 rs74956615 Positive Severe 0.048 1.266 5.50e-10
Variant COVID-19 HGI_rs74956615 Critical vs Controls RAVER1, FDX2, ICAM1, ICAM4, ICAM5, ZGLP1, ICAM3, TYK2 rs74956615 Positive Critical 0.048 1.434 9.71e-12
Variant COVID-19 HGI_rs77534576 Critical vs Controls KAT7, TAC4, DLX3, FLJ45513 rs77534576 Positive Critical 0.033 1.446 4.37e-09