| Population name | Ellinghaus |
| Genome | GRCh38 |
| Consortium | The Severe COVID-19 GWAS group |
| Super population | EUR |
| Population description | Italian and Spanish patients with severe disease defined by respiratory support and hospitalization |
| Population origin | Southern Europe |
| Case population size | 1610 |
| Control population size | 2205 |
| Comorbidities | 49% hypertension, 18.1% diabetes, 10.4% coronary artery disease |
| Mean / median age | 66.7 |
| Sex | male 1096 female 514 |
| Severity | Severe |
| Sample source | Nasopharyngeal swab |
| Method | Genotyping by Illumina Global Screening Array |
| Bioinformatics | PLINK 1.9 logistic-regression for imputation uncertainty. PCA was used for GWA tests with adjustments for population stratification, age and sex. A fixed effects meta-analysis was conducted using METAL. Bayesian fine-mapping performed for loci reaching GW significance. |
| Imputation details | SNP imputation using Michigan Imputation Server and 194,512 haplotypes generated by Trans-Omics for Precision Medicine (TOPMed) |
| Limitations | Limited genotype-phenotype elaboration and therefore adjustment for potential sources of bias; limited information on SARS-CoV-2 infection status in control group; exclusion of genotype samples based on ethnicity. |