| Title | Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women | ||||||||
| DOI | https://doi.org/10.3390/genes12040596 | ||||||||
| Method | Whole exome sequencing | ||||||||
| Curator 1 | megan | ||||||||
| Curator 2 | fatima | ||||||||
| Population | Monticelli | ||||||||
| Published | Yes | ||||||||
| Variant detail | Description of Comparison | Gene | RSID | Association | Disease Status | MAF | Statistical Odds Ratio | Statistical P-value | |
|---|---|---|---|---|---|---|---|---|---|
| Variant | Monticelli_rs12329760 | Mild vs severe | TMPRSS2 | rs12329760 | Positive | Mild | 0.224393 | 0.7601 | 2.89e-02 |
| Variant | Monticelli_rs12329760 | Young males | TMPRSS2 | rs12329760 | Positive | Mild | 0.224393 | 0.5804 | 2.00e-02 |
| Variant | Monticelli_rs12329760 | Elderly women | TMPRSS2 | rs12329760 | Positive | Mild | 0.224393 | 0.5346 | 3.47e-02 |
| Variant | Monticelli_rs12329760 | Young males with comorbidities | TMPRSS2 | rs12329760 | Positive | Mild | 0.224393 | 0.2969 | 5.70e-03 |
| Variant | Monticelli_rs12329760 | Elderly women, comorbidities | TMPRSS2 | rs12329760 | Positive | Mild | 0.224393 | 0.4667 | 3.91e-02 |
| Variant | Monticelli_rs2298659 | Mild vs severe | TMPRSS2 | rs2298659 | Positive | Mild | 0.206982 | 0.6947 | 3.90e-03 |