| Population name | Pairo-Castineira |
| Genome | GRCh37 |
| Consortium | COVID-HGI and 23andMe Inc |
| Super population | EUR |
| Population description | European ancestry hospitalised patients from COVID-19 HGI and those with a broad respiratory phenotype from 23andMe Inc. |
| Population origin | Not specified |
| Case population size | 3543 |
| Control population size | 1157272 |
| Comorbidities | Not specified |
| Mean / median age | not specified |
| Sex | not specified |
| Severity | Severe |
| Sample source | Nasopharyngeal swab / Whole blood |
| Method | Replication analysis was performed using the loci in GenOMICC individuals. Replication analyses were performed using HGI build 37, version 2 ( July 2020) B2 (hospitalized patients with COVID-19 versus the population) GWAS and those defined with respiratory phenotypes in 23andMe Inc. Summary statistics were used from the full analysis, including all cohorts and GWAS without UK Biobank, to avoid sample overlap. |
| Bioinformatics | Meta-analysis of the GenOMICC, HGI and 23andMe datasets was performed using fixed-effect inverse-variance meta-analysis in METAL. |
| Imputation details | Not specified |
| Limitations | Effect sizes are likely to be greater in the GenOMICC study because the cohort is strongly enriched for immediately life-threatening disease. Further studies needed to narrow down the loci found. |