| Title | A common TMPRSS2 variant has a protective effect against severe COVID-19 |
| DOI | https://doi.org/10.1016/j.retram.2022.103333 |
| Method | Genome wide association study |
| Curator 1 | fatima |
| Curator 2 | admin |
| Population | David |
| Published | Yes |
| Variant detail | Description of Comparison | Gene | RSID | Association | Disease Status | MAF | Statistical Odds Ratio | Statistical P-value |
| Variant | David_rs12329760 | COVID-19 severe EUR cases vs control SARS-CoV-2 negative | TMPRSS2 | rs12329760 | negative | Critical | None | 0.87 | 1.00e-02 |
| Variant | David_rs12329760 | Trans-ancestry metanalysis severe vs control SARS-CoV2 negative | TMPRSS2 | rs12329760 | negative | Critical | None | 0.84 | 5.80e-04 |
| Variant | David_rs12329760 | COVID HGI validation hospitalisation vs control general population | TMPRSS2 | rs12329760 | negative | Severe | None | 0.95 | 4.72e-06 |
