Population

Population name Sayin
Genome GRCh38
Consortium Istanbul Training and Research Hospital, Istanbul University
Super population not specified
Population description 200 patients diagnosed with COVID-19 in pandemic clinics of Istanbul University, Faculty of Medicine, between 1 April and 1 June 2020, as well as 100 volunteers without known comorbidities. Gene polymorphism distribution and statistical significance were examined in the following patient groups: (1) severe/mild infection, (2) exitus/ alive during the 28-day follow-up, (3) presence of the need for intensive care/being only inpatient.
Population origin Istanbul, Turkey
Case population size 200
Control population size 100
Comorbidities 26% hypertension
Mean / median age 49 median age
Sex 87 female; 113 male
Severity Severe
Sample source Nasopharyngeal swab
Method DNA isolation from peripheral blood leukocytes of COVID-19 patients and healthy controls was performed using the saline precipitation method. PER3 gene polymorphism genotypes were analyzed by the PCR method.
Bioinformatics IBM SPSS version 21.0 (IBM Corp. USA) for all statistical analyses. P<0.05 was considered statistically significant.
Imputation details NA
Limitations When divided into clinical subgroups, the statistical analysis may have been biased due to the decreased number of patients, and no significant results were obtained in terms of the 5R/5R genotype.