Population name | Sayin |
Genome | GRCh38 |
Consortium | Istanbul Training and Research Hospital, Istanbul University |
Super population | not specified |
Population description | 200 patients diagnosed with COVID-19 in pandemic clinics of Istanbul University, Faculty of Medicine, between 1 April and 1 June 2020, as well as 100 volunteers without known comorbidities. Gene polymorphism distribution and statistical significance were examined in the following patient groups: (1) severe/mild infection, (2) exitus/ alive during the 28-day follow-up, (3) presence of the need for intensive care/being only inpatient. |
Population origin | Istanbul, Turkey |
Case population size | 200 |
Control population size | 100 |
Comorbidities | 26% hypertension |
Mean / median age | 49 median age |
Sex | 87 female; 113 male |
Severity | Severe |
Sample source | Nasopharyngeal swab |
Method | DNA isolation from peripheral blood leukocytes of COVID-19 patients and healthy controls was performed using the saline precipitation method. PER3 gene polymorphism genotypes were analyzed by the PCR method. |
Bioinformatics | IBM SPSS version 21.0 (IBM Corp. USA) for all statistical analyses. P<0.05 was considered statistically significant. |
Imputation details | NA |
Limitations | When divided into clinical subgroups, the statistical analysis may have been biased due to the decreased number of patients, and no significant results were obtained in terms of the 5R/5R genotype. |