| Title | Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease |
| DOI | https://doi.org/10.1038/s41588-021-01006-7 |
| Method | Genome wide association study, Gene Prediction |
| Curator 1 | fatima |
| Curator 2 | admin |
| Population | Horowitz_2 |
| Published | Yes |
| Variant detail | Description of Comparison | Gene | RSID | Association | Disease Status | MAF | Statistical Odds Ratio | Statistical P-value |
| Variant | Horowitz_2_rs11919389 | COVID-19 severe vs not hospitalised | RPL24, CEP97, NXPE3, ZBTB11 | rs11919389 | positive | Severe | None | None | 2.90e-02 |
| Variant | Horowitz_2_rs143334143 | COVID-19 positive vs COVID-19 negative or unknown | CCHCR1 | rs143334143 | positive | Susceptibility | 7.0 | 1.06 | 2.00e-04 |
| Variant | Horowitz_2_rs143334143 | COVID-19 severe vs not hospitalised | CCHCR1 | rs143334143 | positive | Severe | None | 1.14 | 3.06e-02 |
| Variant | Horowitz_2_rs1886814 | COVID-19 severe vs not hospitalised | FOXP4 | rs1886814 | positive | Severe | None | None | 1.80e-02 |
| Variant | Horowitz_2_rs190509934 | COVID-19 positive vs COVID-19 negative or unknown | ACE2 | rs190509934 | negative | Susceptibility | 0.3 | 0.6 | 4.50e-13 |
| Variant | Horowitz_2_rs2109069 | Hospitalised COVID-19 vs negative/unknown | DPP9 | rs2109069 | positive | Susceptibility | 31.0 | 1.1 | 3.00e-07 |
| Variant | Horowitz_2_rs2109069 | COVID-19 hospitalised vs not hospitalised | DPP9 | rs2109069 | positive | Severe | None | 1.08 | 5.66e-04 |
| Variant | Horowitz_2_rs2236757 | Hospitalised COVID-19 vs negative/unknown | IFNAR2 | rs2236757 | positive | Susceptibility | 29.0 | 1.08 | 7.00e-05 |
| Variant | Horowitz_2_rs2236757 | COVID-19 hospitalised vs not hospitalised | IFNAR2 | rs2236757 | positive | Severe | None | 1.08 | 1.76e-03 |
| Variant | Horowitz_2_rs2531743 | COVID-19 positive vs COVID-19 negative | SLC6A20 | rs2531743 | positive | Susceptibility | 42.0 | 0.94 | 3.00e-12 |
| Variant | Horowitz_2_rs73064425 | severe COVID-19 vs COVID-19negative or unknown | LZTFL1, LOC107986083, SLC6A20, SACM1L, CCR9, FYCO1, XCR1, CCR1, CCR3 | rs73064425 | positive | Susceptibility | 7.0 | 1.58 | 2.00e-18 |
| Variant | Horowitz_2_rs73064425 | COVID-19 severe vs not hospitalised | LZTFL1, LOC107986083, SLC6A20, SACM1L, CCR9, FYCO1, XCR1, CCR1, CCR3 | rs73064425 | positive | Severe | None | 1.59 | 4.28e-15 |
| Variant | Horowitz_2_rs879055593 | COVID-19 positive vs COVID-19 negative or unknown | ABO | rs879055593/9411378 | positive | Susceptibility | 24.0 | 1.1 | 7.00e-34 |
