Variant Detail

RSID rs143334143
HGVS NC_000006.11:g.31121426G>A
Chromosome 6
Start position31121426
Stop position31121426
Associated gene(s)MHC (CCHCR1)
Mutation typeTagged SNP
Reference G
Alternative A
Associated allele A
Associated African Allele Frequency 0.0468
Consequence Intronic
Other population frequencies linkALFA rs143334143

Variants

NamePaperDescription of ComparisonGeneRSIDAssociationDisease StatusMAFStatistical Odds RatioStatistical P-value
Horowitz_rs143334143 Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease Meta analysis, External data MHC (CCHCR1) rs143334143 Positive Severe 0.07 1.36 0.0006
Pairo-Castineira_rs143334143 Genetic mechanisms of critical illness in Covid-19 Critical COVID vs controls UKB CCHCR1 rs143334143 Positive Critical None 1.8 0.0000000000000000088
Pairo-Castineira_rs143334143 Genetic mechanisms of critical illness in Covid-19 hospitalised vs controls CCHCR1 rs143334143 Positive Severe None 1.3 0.00000000015
Horowitz_2_rs143334143 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease COVID-19 positive vs COVID-19 negative or unknown CCHCR1 rs143334143 positive Susceptibility 7.0 1.06 0.0002
Horowitz_2_rs143334143 Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease COVID-19 severe vs not hospitalised CCHCR1 rs143334143 positive Severe None 1.14 0.0306

Papers

Paper
Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease
Genetic mechanisms of critical illness in Covid-19
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease